HUBUNGAN ANTARA KADAR INTERLEUKIN 6 DENGANSKOR CHILD-PUGH PADA PENDERITA SIROSIS HATI
Chronic liver disease and cirrhosis is the ninth leading cause of death in the United States and responsible for 1.2% of all deaths in the United States. High morbidity and mortality due to complications of cirrhosis. Assessing the prognosis of patients with liver cirrhosis is used Child Pugh score...
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| Main Authors: | , |
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| 格式: | Theses and Dissertations NonPeerReviewed |
| 出版: |
[Yogyakarta] : Universitas Gadjah Mada
2014
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| 在線閱讀: | https://repository.ugm.ac.id/128492/ http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=68840 |
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| 機構: | Universitas Gadjah Mada |
| 總結: | Chronic liver disease and cirrhosis is the ninth leading cause of death in the
United States and responsible for 1.2% of all deaths in the United States. High
morbidity and mortality due to complications of cirrhosis. Assessing the prognosis of
patients with liver cirrhosis is used Child Pugh score modification which based on the
severity of the disease according to the signs, symptoms and laboratory test results, the
variables include the levels of bilirubin, albumin, INR, elongation parsial protrombine
Time (PPT), presence or absence of ascites and encephalopathy. This classification
consists of Child A, B, and C. Cytokines are molecules that play a role in the complex
physiological and pathological processes that occur in the liver. Interleukin 6 levels are
elevated in patients with hepatitis, especially in patients with liver cirrhosis and
hepatocellular carcinoma (KHS). Interleukin 6 levels can be used as a marker of liver
disease progression than using invasive methods.
The aim of this study was to assess correlation between interleukin-6 levels with
severity of liver cirrhosis by using with Child Pugh score modification.
The study design was cross-sectional method. Subject of this study collected
with consecutive sampling. Subjects of this study were liver cirrhosis patients who
were treated in the inpatient clinic and patient in ward in internal department of dr.
RSUP dr. Sardjito since November 2011 until November 2012. The relationship
between levels of interleukin 6 with Child Pugh scores modification using Spearman
correlation test. The relationship is considered significant when P <0.05. The results
showed increased levels of IL-6 with increasing Child-Pugh score modification, but this
increase was not statistically significant (r = 0.09, p = 0.57).
Conclussion: This study showed that raising of IL-6 levels is followed with
increasing of Child-Pugh Score modification but this correlation is weak and not
statistically significant |
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