PERBEDAAN EKSPRESI INTERLEUKIN-10 BERDASARKAN DERAJAT HISTOPATOLOGIK PERADANGAN MUKOSA GASTER GASTRITIS KRONIK DENGAN INFEKSI HELICOBACTER PYLORI

• المؤلفون الرئيسيون: , Febie Chriestya, , dr. Neneng Ratnasari, SpPD-KGEH
• التنسيق: Theses and Dissertations NonPeerReviewed
• منشور في: [Yogyakarta] : Universitas Gadjah Mada 2014
• الموضوعات: ETD
• الوصول للمادة أونلاين: https://repository.ugm.ac.id/128281/; http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=68620

The incidence of Helicobacter pylori infection in Indonesia is very high, but the degree of severity of gastritis and the risk of developing gastric cancer is extremely low. Interleukin-10 (IL-10) is an anti-inflammatory cytokine that is considered to play a strong role in determining the grade of severity of gastric mucosal inflammation due to H. pylori infection. This study aimed to determine the comparison of IL-10 expression based on the grade of histopathological inflammation of gastric mucosa in patients with H. pylori-infected chronic gastritis. This study was a retrospective study, the design of study was cross sectional. The study was conducted by examining the histopathological biopsy specimens of 42 chronic gastritis patients (aged 18-80 years) who had undergone endoscopy at Dr. Sardjito Hospital. Samples were excluded if based on patient�s medical record data, the patient was known to have a history of gastroesophageal reflux disease, malignancy, autoimmune disease, renal failure and chronic liver disease. A higher mean/median of IL-10 expression tended to be found in: the group with mild grade of gastric mucosal inflammation compared to the moderate-to-severe group (46,38 ± 10,30% vs 36,83 ± 17,58)