PENGARUH KADAR ESTRADIOL BASAL TERHADAP MELASMA

• Main Authors: , Dwi Rakhmawati, , dr. Prasetyadi Mawardi, Sp.KK
• 格式: Theses and Dissertations NonPeerReviewed
• 出版: [Yogyakarta] : Universitas Gadjah Mada 2013
• 主題: ETD
• 在線閱讀: https://repository.ugm.ac.id/119913/; http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=59919
• 機構: Universitas Gadjah Mada

Background:Melasma is one of the most common hyperpigmentation lesions. About 5 million Americans suffer from it, and contributed on 45,9 percent of patients at the DVoutpatient clinic on DrMoewardi. The pathogenesis of melasma is still uncertain. Hormonal factors, genetic, and ultraviolet radiation (UV) widely cited by the literatures as the most important etiopathologic factors of melasma. The controversies of those are still in debate. Basal estradiol levels regarded as estrogen levels with the highest potential activity for melanogenesis, melanositosis, and deposition of melanin pigment. Basal estradiol also has known to have a narrow range of variation, thus benefiting reduce research bias. The study is expected to clarify the etiopathologymelasma by hormonal factors, especially estrogen. Methods: Observational analytic study using a case controldesign. Estrogen levels are determined by examination of basal estradiol levels. Blood serum samples were taken from one-time pick-up between the 2 nd day until the 5 th day of menstrual period. Then it will be quantitatified by ELISA. Statistical analysis was done by using the parametric test using t-test for measuring the differences of mean basal estradiol levels between the groups with melasmaand non-melasma. Data distribution evidenced normal by Shaporo-Wilk. The relationship between MASI score and the basal estradiol levels analyzed by Pearson's correlation.Significance obtained by p value less than 0.05. Results: Forty-four subject met the inclusion criteria. Then equally divided into two groups, melasma and non-melasma. From the characteristics of the subjects, the study found a significant difference between the BMI and age(p <0.05). These foundings are explaining other etiopathologyof melasma other than estrogen. These explain others etiopathology of melasma, beyond the role of basal estradiol levels. Mean value of basal estradiol levels on melasma group (76.705 pg) was higher than on non-melasma group (70.714 pg). Eventhough, this difference was not statistically significant. There is a weak positive correlation between basal estradiol levels and MASI scores, although insignificant on statistical results (p = 0.0799 and r = 0.063). Conclusions: The hypothesis about the role of basal estradiol levels did not prove to be significant in the etiopathogenesisof melasma. Other factors have a predictable influence on the occurrence of melasma (BMIand age)