PENGARUH KADAR PROPILEN GLIKOL, TWEEN 80 DAN BESAR ARUS IONTOFORESIS TERHADAP TRANSPOR TRANSDERMAL PROMETAZIN HCL SECARA IN VITRO

• Main Authors: , Dwi Nurahmanto, , Prof. Dr. Marchaban, DESS., Apt
• Format: Theses and Dissertations NonPeerReviewed
• Published: [Yogyakarta] : Universitas Gadjah Mada 2013
• Subjects: ETD
• Online Access: https://repository.ugm.ac.id/119543/; http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=59546

Promethazine HCl undergoes extensive hepatic first-pass metabolism following oral administration resulted in a low bioavailability at around 25%. Oral absorption is often interrupted by nausea and vomiting, so the bioavalability is low and morning sickness is not treated verry well. The purposes of...