ELUSIDASI STRUKTUR PRODUK SAMPING DARI HASIL SINTESIS SENYAWA THPGV-1 DAN UJI ANTIINFLAMASI SENYAWA THPGV-1

• المؤلفون الرئيسيون: , Fransiska Ayuningtyas Widyastani, , Dr. Ritmaleni, S.Si
• التنسيق: Theses and Dissertations NonPeerReviewed
• منشور في: [Yogyakarta] : Universitas Gadjah Mada 2013
• الموضوعات: ETD
• الوصول للمادة أونلاين: https://repository.ugm.ac.id/118907/; http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=58885
• المؤسسة: Universitas Gadjah Mada

THPGV-1 has been sucesfully synthesised by using the hydrogenation reaction methode where Pd/C was used as catalyst, hydrogen gas as source of hydrogen and PGV-1 as starting material. The reaction was carried out at room temperature for two hours and yielded THPGV-1 in 18% and three others side products. The aim of this research was to elucidate this sructure of side products and to investigate the anti-inflamatory activity of THPGV-1. Structure elucidations were carried out by using the spectroscopic method (1H-NMR, 2D-NMR, IR and MS) and anti-inflamatory activity was performed by the method of carragenan-induced footpad edema. Anti-inflamtory activity THPGV-1 admnistered orally to mice a moment before carragenan injection. THPGV-1 was comparable to PGV-1. Swelling measurements performed every 30 minutes for 6 hours using calipers. The side products� structures are found 1,3-bis-(4'-hydroxy-3',5'-dimethyl) benzylcyclopentane (compound A) in 30.33% yield as white crystalline powder with MW= 338 g/mol, 2,5-bis-(4�-hydroxy-3�,5�-dimethyl)benzylcyclopentanol (compound B) in 7.04% yield as white crystalline powder with MW= 354 g/mol and and compound C is an isomer of compound B in 15.38% yield as white crystalline powder with MW= 354 g/mol. Anti-inflammatory activity can be seen in the results of that test in different dossage are 60,80,100,120 mg /Kg body weight with anti-inflamation zone percentage respectively 69.97 ± 1.71%