Ekspresi Reseptor FcγII (CD32)Monosit pada Pasien Infeksi Dengue dan Subyek Sehat
Dengue infection is a global threat and an endemic or epidemic disease in almost countries especially in tropical and subtropical regions, including Indonesia. Since it was first discovered in 1968 until 2009, the World Health Organization (WHO) noted Indonesia as a country with the highest cases of...
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| Main Authors: | , |
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| Format: | Theses and Dissertations NonPeerReviewed |
| Published: |
[Yogyakarta] : Universitas Gadjah Mada
2012
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| Subjects: | |
| Online Access: | https://repository.ugm.ac.id/101091/ http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=58006 |
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| Summary: | Dengue infection is a global threat and an endemic or epidemic disease in
almost countries especially in tropical and subtropical regions, including
Indonesia. Since it was first discovered in 1968 until 2009, the World Health
Organization (WHO) noted Indonesia as a country with the highest cases of
dengue hemorrhagic fever (DHF) in Southeast Asia. Manifestations of dengue
infection vary widely, and it can be asymptomatic or symptomatic, such as the
undifferentiated fever, dengue fever (DF), DHF or dengue shock syndrome (DSS).
Antibody-dependent enhancement (ADE) is one of the central hypotheses
for the pathogenesis of DHF/DSS that hadbeen proposed 3 decades ago.
Preexisting antibodies to one serotype form infectious immune complexes
withheterotypic serotypes and bind to FcγII receptor such as
monocytes/macrophages. This facilitates the entry of dengue virus / DENV,
replication, and spread which willincreasing the degree of the disease severity.
This study is an observational analytic study with a cross-sectional design
to determine expression of FcγIIR (CD32) monocytes in patient with dengue
infection and healthy subject. The study subjects were patients with DENV
infection based on WHO 2011 criteria, hospitalized in RSUPDR. Sardjito
Yogyakarta andRSUD Panembahan Senopati Bantul, and resident/relatives with
consecutive selected and meet the criteria for inclusion or exclusion. Examination
expression of FcγIIR (CD32) monocytes in whole boodwith lyse no wash
principle using flowcytometry. The results shown in the descriptive analysis and
analysis of differences expression of FcγIIR (CD32) monocytes in patients with
dengue infection and healthy subjects.Expressionof FcγIIR (CD32) monocytes in
patients with dengue infection higher than healthy subjects. |
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