Comparison of Bladder Cancer Cells Apoptosis Induced by Metformin, Cisplatin, and Combination of Metformin-Cisplatin: In Vitro Study

• Main Authors: Arifai Lumbangaol, Lukman Hakim, Doddy M. Soebadi, Tarmono Djojodimedjo
• 格式: Article PeerReviewed
• 語言: English; English; English; English
• 出版: The Indonesian Urological Association 2020
• 主題: R Medicine (General); RD Surgery
• 在線閱讀: http://repository.unair.ac.id/95458/1/Comparison%20of%20Bladder%20Cancer%20Cells.pdf; http://repository.unair.ac.id/95458/2/Comparisn%20of%20Bladder%20Cancer%20Cells%20Apoptosis%20Induced%20by%20Metformin%2C%20Ciplastin%2C%20and%20Combination%20of%20Metformin-Cisplatin.pdf; http://repository.unair.ac.id/95458/3/Comparisn%20of%20Bladder%20Cancer%20Cells%20Apoptosis%20Induced%20by%20Metformin%2C%20Ciplastin%2C%20and%20Combination%20of%20Metformin-Cisplatin%20edit%20%281%29.pdf; http://repository.unair.ac.id/95458/7/Comparison%20of%20Bladder%20Cancer.pdf; http://repository.unair.ac.id/95458/; http://juri.urologi.or.id/juri/article/view/600; https://doi.org/10.32421/juri.v27i1.600

Objective: To evaluate the effect of metformin, cisplatin, and their combination on apoptosis of bladder cancer cells. Material & Methods: Urothelial cell lines 5637 were cultured until 80% confluence. Cells were exposed to metformin and cisplatin at certain doses for 24 and 48 hours. Cytotoxici...