Identification of Physical Interaction in Binary Systems of Acyclovir–Succinic Acid

Acyclovir, a guanosine analogue antiviral drug with low solubility of water. Due to its poorsolubility and permeability, causes low oral bioavailability.Objective:The aim of this research is toinvestigatethe physical interaction in binary systems acyclovir-succinic acid (AS).Methods:Themsystemwas pr...

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Main Authors:	Winantari, Agnes Nuniek, Setyawan, Dwi, Siswandono, Siswandono
Format:	Article PeerReviewed
Language:	English English
Published:	Fakultas Farmasi Universitas Airlangga 2016
Subjects:	RS Pharmacy and materia medica RS1-441 Pharmacy and materia medica RS200-201 Pharmaceutical dosage forms
Online Access:	http://repository.unair.ac.id/75692/1/C-23%20Artikel.pdf http://repository.unair.ac.id/75692/2/C-23%20Validasi%20dan%20Peer%20Reviewer.pdf http://repository.unair.ac.id/75692/
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spelling	id-langga.756922018-11-21T15:26:59Z http://repository.unair.ac.id/75692/ Identification of Physical Interaction in Binary Systems of Acyclovir–Succinic Acid Winantari, Agnes Nuniek Setyawan, Dwi Siswandono, Siswandono RS Pharmacy and materia medica RS1-441 Pharmacy and materia medica RS200-201 Pharmaceutical dosage forms Acyclovir, a guanosine analogue antiviral drug with low solubility of water. Due to its poorsolubility and permeability, causes low oral bioavailability.Objective:The aim of this research is toinvestigatethe physical interaction in binary systems acyclovir-succinic acid (AS).Methods:Themsystemwas prepared by solvent evaporation method.Results:Thermogram Differential Scanning Calorimetryshowed endothermic peaks at 172.68 o C(ethanol) and 171.84 o C (methanol). The Powder X-RayDiffraction (PXRD) pattern of ASwasdifferent from pure component and physical mixtures. Furthermore,physical characterization showed the binary system of AS have unique crystal habit by polarizationmicroscope.Conclusion:New crystalline phase is formed from the interaction between acyclovir andsuccinic acid by solvent evaporation methodusing ethanol and methanol.Keywords:physical interaction, acyclovir, succinic acid, binary systems Fakultas Farmasi Universitas Airlangga 2016 Article PeerReviewed text en http://repository.unair.ac.id/75692/1/C-23%20Artikel.pdf text en http://repository.unair.ac.id/75692/2/C-23%20Validasi%20dan%20Peer%20Reviewer.pdf Winantari, Agnes Nuniek and Setyawan, Dwi and Siswandono, Siswandono (2016) Identification of Physical Interaction in Binary Systems of Acyclovir–Succinic Acid. Jurnal Farmasi dan Ilmu Kefarmasian Indonesia, 3 (1). pp. 27-31. ISSN 2406-9388
institution	Universitas Airlangga
building	Universitas Airlangga Library
country	Indonesia
collection	UNAIR Repository
language	English English
topic	RS Pharmacy and materia medica RS1-441 Pharmacy and materia medica RS200-201 Pharmaceutical dosage forms
spellingShingle	RS Pharmacy and materia medica RS1-441 Pharmacy and materia medica RS200-201 Pharmaceutical dosage forms Winantari, Agnes Nuniek Setyawan, Dwi Siswandono, Siswandono Identification of Physical Interaction in Binary Systems of Acyclovir–Succinic Acid
description	Acyclovir, a guanosine analogue antiviral drug with low solubility of water. Due to its poorsolubility and permeability, causes low oral bioavailability.Objective:The aim of this research is toinvestigatethe physical interaction in binary systems acyclovir-succinic acid (AS).Methods:Themsystemwas prepared by solvent evaporation method.Results:Thermogram Differential Scanning Calorimetryshowed endothermic peaks at 172.68 o C(ethanol) and 171.84 o C (methanol). The Powder X-RayDiffraction (PXRD) pattern of ASwasdifferent from pure component and physical mixtures. Furthermore,physical characterization showed the binary system of AS have unique crystal habit by polarizationmicroscope.Conclusion:New crystalline phase is formed from the interaction between acyclovir andsuccinic acid by solvent evaporation methodusing ethanol and methanol.Keywords:physical interaction, acyclovir, succinic acid, binary systems
format	Article PeerReviewed
author	Winantari, Agnes Nuniek Setyawan, Dwi Siswandono, Siswandono
author_facet	Winantari, Agnes Nuniek Setyawan, Dwi Siswandono, Siswandono
author_sort	Winantari, Agnes Nuniek
title	Identification of Physical Interaction in Binary Systems of Acyclovir–Succinic Acid
title_short	Identification of Physical Interaction in Binary Systems of Acyclovir–Succinic Acid
title_full	Identification of Physical Interaction in Binary Systems of Acyclovir–Succinic Acid
title_fullStr	Identification of Physical Interaction in Binary Systems of Acyclovir–Succinic Acid
title_full_unstemmed	Identification of Physical Interaction in Binary Systems of Acyclovir–Succinic Acid
title_sort	identification of physical interaction in binary systems of acyclovir–succinic acid
publisher	Fakultas Farmasi Universitas Airlangga
publishDate	2016
url	http://repository.unair.ac.id/75692/1/C-23%20Artikel.pdf http://repository.unair.ac.id/75692/2/C-23%20Validasi%20dan%20Peer%20Reviewer.pdf http://repository.unair.ac.id/75692/
_version_	1681150489857622016

Identification of Physical Interaction in Binary Systems of Acyclovir–Succinic Acid

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