Effect of Al(OH)2 and Mg (OH)2 Suspension Dosage Form on the Absorption of Oral Ciprofloxacin
Potential interaction of fluroquinolone with other drugs have been established in the several reports. The absorption of fluroquinolones were almost entirely inhibited by concomitant administration of di and trivalent cations such magnesium and aluminium in the antacids were significantly decrease...
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| Main Authors: | , , |
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| 格式: | Article PeerReviewed |
| 語言: | English English English |
| 出版: |
2008
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| 主題: | |
| 在線閱讀: | http://repository.unair.ac.id/73176/1/C-6%20Artikel%20Jurnal.pdf http://repository.unair.ac.id/73176/2/C-6%20Peer%20Reviewer.pdf http://repository.unair.ac.id/73176/13/C-06%20Result%2827%25%29.pdf http://repository.unair.ac.id/73176/ http://id.portalgaruda.org/index.php/ref=browse&mod=viewarticle&article=18384?ref=browse&mod=viewarticle&article=18384 |
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| 總結: | Potential interaction of fluroquinolone with other drugs have been established in the several reports.
The absorption of fluroquinolones were almost entirely inhibited by concomitant administration of di and
trivalent cations such magnesium and aluminium in the antacids were significantly decreased the
absorption of ciprofloxacin through formation of a complex. The effect of antacid (Antasida DOEN) 1.4
ml/kg body weight doses which containing polyvalent cation Mg (OH)
2
and Al(OH)
3
on the absorption of
ciprofloxacin. were examed in healthy rabbit. Twelve subjects were given 23 mg/ml BW ciprofloxacin
alone as control. On day 8 the six subjects were given antacid and ciprofloxacin concomitant and the
other were given antacid two hours after ciprofloxacin. The absorption parameters of ciprofloxacin were
determined by spectrofluorometric method. Those parameters were Cmax, tmax and AUC, the
administration of ciprofloxacin and antacids concomitantly result Cmax, tmax and AUC were
1.27±0.45g/ml; 110±48.99 minutes and 248.63±94.77g.minutes/ml respectively in a significant
decrease in ciprofloxacin absorption (p<0.05) and the administration of antacids two hours after
ciprofloxacin result Cmax, tmax and AUC were 1.37±0.65g/ml;75±36.74 minutes and 245.09±100.46
g.minutes/ml respectively in a significant decrease in ciprofloxacin absorption (p<0.05). Percentages
of relative bioavailability compared with control values were 27.06±16.70% and 8.77±6.97% for
concomitant and two hours after ciprofloxacin respectively.
Keywords: Ciprofloxacin, Mg(OH)2, Al(OH)3, antacid, pectrofluorometric |
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