Pengaruh Sirkadian Pada Farmakokinetika Sulfametoksazol Oral Dengan Data Darah Kelinci
The objective of this study was to determine the effect of circadian on pharmacokinetics variation of orally administered sulfamethoxazole in rabbit. Circadian variations of sulfamethoxazole pharmacokinetics were studied after a single oral administration sulfamethoxazole, 50 mg/kg bw, given at 0...
محفوظ في:
| المؤلفون الرئيسيون: | , , |
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| التنسيق: | مقال PeerReviewed |
| اللغة: | English English English |
| منشور في: |
Majalah Farmasi Airlangga
2009
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| الموضوعات: | |
| الوصول للمادة أونلاين: | http://repository.unair.ac.id/73142/19/C-7%20Artikel%20Jurnal.pdf http://repository.unair.ac.id/73142/3/C-7%20Peer%20Reviewer.pdf http://repository.unair.ac.id/73142/1/c-07%20Result%20%286%25%29.pdf http://repository.unair.ac.id/73142/ http://download.portalgaruda.org/article.php?article=18402&val=1142 |
| الوسوم: |
إضافة وسم
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|
| المؤسسة: | Universitas Airlangga |
| اللغة: | English English English |
| الملخص: | The objective of this study was to determine the effect of circadian on pharmacokinetics
variation of orally administered sulfamethoxazole in rabbit. Circadian variations of
sulfamethoxazole pharmacokinetics were studied after a single oral administration
sulfamethoxazole, 50 mg/kg bw, given at 09.00 a.m and 09.00 pm. Blood sample was taken from
0.25; 0.50; 1.00; 1.50; 2.00 ; 4.00 ; 6.00 ; 9.00; 12.00 ; 24.00 hours. Using spectrophotometer
UV-VIS, the pharmacokinetics parameter was calculate for Area Under Curve (AUC),
elimination rate constant (k
e
), and half life (t ½). From statistical analysis it could be seen that
there were significant difference on AUC 09.00 am and 21.00 pm but not in elimination rate
constant (k
e
) and halflife (t ½). The AUC was significantly smaller in the morning
(2674.571±452.660 µg/ml.minutes) than in the nighttime (4536.532±1534.370 µg/ml.minutes)
(p<0.05). The elimination rate constant (k
e
) was not significantly increased in the morning
(0.012±0.003/minutes) than in the night time (0.009±0.008/minutes) (p>0.05). The half-life (t
1/2
)
was not significantly shorter in the morning (34.000±2.550 minutes) than the night time
(58.200±0.840 minutes) (p>0.05). Overall, the results shows the difference characteristic of
pharmacokinetics due to the circadian time.
Keyword : Circadian, pharmacokinetics, sulfamethoxazole |
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