Antimalarial Properties of Streptomyces hygroscopicus subsp Hygroscopicus Secondary Metabolite Active Fractions: In Silico and In Vivo Analysis

• Main Authors: Loeki E Fitri, -, Ajeng M Putri, -, Nabila E Erwan, -, Fitria F Putri, -, Rivo Y B Nugraha, -, Teguh W Sardjono, -, Kana Mardhiyyah, -, Dio G Ariel, -, Icha F D Faratisha, -, Suciati, -, Bachtiar R P Ihsan, -, Sri Winarsih, -
• Format: Article PeerReviewed
• Language: English; English; English
• Published: Advanced Scientific Research 2021
• Subjects: R Medicine; RS Pharmacy and materia medica; RS1-441 Pharmacy and materia medica; RS200-201 Pharmaceutical dosage forms
• Online Access: https://repository.unair.ac.id/125062/1/C-18_Artikel.pdf; https://repository.unair.ac.id/125062/2/C-18%20kualitas%20karil%20dan%20validasi%20kadep.pdf; https://repository.unair.ac.id/125062/5/C-18_Similarity.pdf; https://repository.unair.ac.id/125062/; http://www.ijpronline.com/ViewArticleDetail.aspx?ID=18847; https://doi.org/10.31838/ijpr/2021.13.01.321

Background: Crude extract of Streptomyces hygroscopicus has antimalarial effect in vivo and its active fractions showed Plasmodium inhibition in vitro. This study aims to analyze the antimalarial activity of fraction 41 and 44 of S.hygroscopicus in vivo and predict their antimalarial mechanism in si...