Biocompatibility Of Yttria-Tetragonal Zirconia Polycrystal Seeded With Human Adipose Derived Mesenchymal Stem Cell
ABSTRACT Introduction: The scaffold is a place for regeneration of new bone and bone tissue growths in tissue engineering applications. hADMSC is a multipotent cell which can differentiate into osteogenic, chondrogenic and adipogenic. Y-TZP has been shown to have several advantages over other c...
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| المؤلفون الرئيسيون: | , , , , , , |
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| التنسيق: | مقال PeerReviewed |
| اللغة: | English Indonesian English English |
| منشور في: |
Avicena Publishing
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| الموضوعات: | |
| الوصول للمادة أونلاين: | https://repository.unair.ac.id/124784/1/2%20artikel.pdf https://repository.unair.ac.id/124784/2/2.%20karil.pdf https://repository.unair.ac.id/124784/3/2.%20Korespondensi.pdf https://repository.unair.ac.id/124784/4/2.%20turnitin.pdf https://repository.unair.ac.id/124784/ https://www.ejmanager.com/mnstemps/6/6-1543998572.pdf?t=1670399029 https://dx.doi.org/10.5455%2Faim.2018.26.249-253 |
| الوسوم: |
إضافة وسم
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| المؤسسة: | Universitas Airlangga |
| اللغة: | English Indonesian English English |
| الملخص: | ABSTRACT
Introduction: The scaffold is a place for regeneration of new bone and bone tissue growths in tissue
engineering applications. hADMSC is a multipotent cell which can differentiate into osteogenic,
chondrogenic and adipogenic. Y-TZP has been shown to have several advantages over other ceramics
because of its hard nature, namely fracture toughness and high flexural strength. Aim: This study
aimed to analyze the biocompatibility of Y-TZP as a scaffold seeded with hADMSCs by in vitro analysis.
Material and Methods: This research involved several processes, namely Y-TZPS manufacture pro�cess, XRD examination, differentiation and characterization of hADMSC, SEM observation, and then
TT. Results: The results of the XRD examination showed that Y-TZPSs had sharp peaks. It suggests
that they had high crystal purity. The marked expression of the characterization of hADMSC is the
positive expression of Cluster of differentiation (CD), namely CD 90, CD 73 and CD 105 above NMT
and negative expressions of CD 14, CD 19, CD 34, CD 45 and also HLA-DR below NLT. The analysis of
observations on the Y-TZPSs with SEM, subsequently, indicated the porosity of Y-TZPSs, as a result, the
adhesion of HADMSCs occurred and grew in the porosity in the Y-TZPSs. Conclusions: Y-TZPSs with
low porosity and toxicity can be able to proliferate and differentiate if seeded with hADMSC. Y-TZPSs
are expected to be used as implantable biomaterials using hADMSCs with high biocompatibility. |
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