Alstiphyllanines E–H, picraline and ajmaline-type alkaloids from Alstonia macrophylla inhibiting sodium glucose cotransporter

• Main Authors: Hiroko Arai, -, Yusuke Hirasawa, -, Abdul Rahman, -, Idha Kusumawati, -, Noor Cholies Zaini, -, Seizo Sato, -, Chihiro Aoyama, -, Jiro Takeo, -, Hiroshi Morita, -
• Format: Article PeerReviewed
• Language: English; English; English
• Published: Elsevier Ltd. 2010
• Subjects: R Medicine; RS Pharmacy and materia medica; RS1-441 Pharmacy and materia medica; RS200-201 Pharmaceutical dosage forms
• Online Access: https://repository.unair.ac.id/117002/1/C-18%20Artikel.pdf; https://repository.unair.ac.id/117002/7/C-18%20Kualitas%20Karil.pdf; https://repository.unair.ac.id/117002/3/C-18%20Similarity.pdf; https://repository.unair.ac.id/117002/; https://www.sciencedirect.com/science/article/abs/pii/S0968089610001082; https://doi.org/10.1016/j.bmc.2010.01.077
• Institution: Universitas Airlangga

Three new picraline-type alkaloids, alstiphyllanines E–G (1–3) and a new ajmaline-type alkaloid, alstiphyllanine H (4) were isolated from the leaves of Alstonia macrophylla together with 16 related alkaloids (5–20). Structures and stereochemistry of 1–4 were fully elucidated and characterized by 2D...