ควอนตัมดอทที่ทำให้เสถียรด้วยพอลิเมอร์คอนจูเกตกับแมนโนสสำหรับการตรวจติดตามทางชีวภาพ
This research aims to prepare water-soluble and biocompatible quantum dots (QDs) that are capable of targeting abnormal cells having enriched mannose receptors. 2’- Aminoethyl-α-D-mannopyranoside was first synthesized from 1,2,3,4,6-penta-O-acetyl-Dmannopyranose via 3-step reaction; glycosylation, d...
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| 格式: | Senior Project |
| 語言: | Thai |
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จุฬาลงกรณ์มหาวิทยาลัย
2015
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| 主題: | |
| 在線閱讀: | https://digiverse.chula.ac.th/Info/item/dc:9944 |
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| 機構: | Chulalongkorn University |
| 語言: | Thai |
| 總結: | This research aims to prepare water-soluble and biocompatible quantum dots (QDs) that are capable of targeting abnormal cells having enriched mannose receptors. 2’- Aminoethyl-α-D-mannopyranoside was first synthesized from 1,2,3,4,6-penta-O-acetyl-Dmannopyranose via 3-step reaction; glycosylation, deprotection, and hydrogenation. The synthesized mannose derivative was then conjugated with poly(methacrylic acid)-co-(2- methacryloyloxyethyl phosphorylcholine) (PMAMPC) having targeted degree of polymerization of 100 and comonomer ratio (MA:MPC) of 60:40 that was synthesized by RAFT polymerization employing ethyl(dimethylaminopropyl) carbodiimide (EDC)/ N-hydroxysuccinimide (NHS) as coupling reagents and yielded PMAMPC-mannose. Chemical structures of all products obtained in each step of reactions were verified by ¹H NMR and FT-IR spectroscopy. Due to the low stability of the original QDs, we were unsuccessful in preparing QDs stabilized with PMAMPC-mannose via ligand exchange using ethanolamine as temporary soft-binding ligand. |
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