ควอนตัมดอทที่ทำให้เสถียรด้วยพอลิเมอร์คอนจูเกตกับแมนโนสสำหรับการตรวจติดตามทางชีวภาพ

• المؤلف الرئيسي: ณัฐณิชา เลิศอมรมีสุข
• مؤلفون آخرون: วรวีร์ โฮเว่น
• التنسيق: Senior Project
• اللغة: Thai
• منشور في: จุฬาลงกรณ์มหาวิทยาลัย 2015
• الموضوعات: ควอนตัมดอต; สารกึ่งตัวนำ
• الوصول للمادة أونلاين: https://digiverse.chula.ac.th/Info/item/dc:9944

This research aims to prepare water-soluble and biocompatible quantum dots (QDs) that are capable of targeting abnormal cells having enriched mannose receptors. 2’- Aminoethyl-α-D-mannopyranoside was first synthesized from 1,2,3,4,6-penta-O-acetyl-Dmannopyranose via 3-step reaction; glycosylation, deprotection, and hydrogenation. The synthesized mannose derivative was then conjugated with poly(methacrylic acid)-co-(2- methacryloyloxyethyl phosphorylcholine) (PMAMPC) having targeted degree of polymerization of 100 and comonomer ratio (MA:MPC) of 60:40 that was synthesized by RAFT polymerization employing ethyl(dimethylaminopropyl) carbodiimide (EDC)/ N-hydroxysuccinimide (NHS) as coupling reagents and yielded PMAMPC-mannose. Chemical structures of all products obtained in each step of reactions were verified by ¹H NMR and FT-IR spectroscopy. Due to the low stability of the original QDs, we were unsuccessful in preparing QDs stabilized with PMAMPC-mannose via ligand exchange using ethanolamine as temporary soft-binding ligand.