A first-in-human randomized, double-blind, placebo-controlled, single- and multiple-ascending oral dose study of novel imidazolopiperazine KAF156 to assess its safety, tolerability...

بواسطة Leong, F.J, Zhao, R, Zeng, S, Magnusson, B, Diagana, T.T, Pertel, P
منشور في 2020

A first-in-human randomized, double-blind, placebo-controlled, single- And multiple-ascending oral dose study of novel antimalarial spiroindolone KAE609 (cipargamin) to assess its...

بواسطة Leong, F.J, Li, R, Jain, J.P, Lefèvre, G, Magnusson, B, Diagana, T.T, Partel, P
منشور في 2020

Pharmacokinetic-pharmacodynamic analysis of spiroindolone analogs and KAE609 in a murine malaria model

بواسطة Lakshminarayana S.B., Freymond C., Fischli C., Yu J., Weber S., Goh A., Yeung B.K.S., Ho, Chi Lui Paul, Dartois V., Diagana T.T., Rottmann M., Blasco F.
منشور في 2016

Imidazolopiperazines kill both rings and dormant rings in wild-type and K13 artemisinin-resistant plasmodium falciparum In Vitro

بواسطة Laurent Dembele, Devendra Kumar Gupta, Michelle Yi Xiu Lim, Xiaoman Ang, Jeremy J. Selva, Kesinee Chotivanich, Chea Nguon, Arjen M. Dondorp, Ghislain M.C. Bonamy, Thierry T. Diagana, Pablo Bifania
منشور في 2019

Imidazolopiperazines kill both rings and dormant rings in wild-type and K13 artemisinin-resistant plasmodium falciparum In Vitro

بواسطة Dembele, L, Gupta, D.K, Lim, M.Y.-X, Ang, X, Selva, J.J, Chotivanich, K, Nguon, C, Dondorp, A.M, Bonamy, G.M.C, Diagana, T.T, Bifania, P
منشور في 2020

Spiroindolone KAE609 for falciparum and vivax malaria

بواسطة Nicholas J. White, Sasithon Pukrittayakamee, Aung Pyae Phyo, Ronnatrai Rueangweerayut, François Nosten, Podjanee Jittamala, Atthanee Jeeyapant, Jay Prakash Jain, Gilbert Lefèvre, Ruobing Li, Baldur Magnusson, Thierry T. Diagana, F. Joel Leong
منشور في 2018

PI4 kinase is a prophylactic but not radical curative target in Plasmodium vivax-type malaria parasites

بواسطة Zeeman, A.-M, Lakshminarayana, S.B, Van Der Werff, N, Klooster, E.J, Voorberg-Van Der Wel, A, Kondreddi, R.R, Bodenreider, C, Simon, O, Sauerwein, R, Yeung, B.K.S, Diagana, T.T, Kocken, C.H.M
منشور في 2020

The plasmodium liver-specific protein 2 (LISP2) is an early marker of liver stage development

بواسطة Gupta, D.K., Dembele, L., Voorberg-Van Der Wel, A., Roma, G., Yip, A., Chuenchob, V., Kangwanrangsan, N., Ishino, T., Vaughan, A.M., Kappe, S.H., Flannery, E.L., Sattabongko, J., Mikolajczak, S., Bifani, P., Kocken, C.H.M., Diagana, T.T.
منشور في 2021

The Plasmodium PI(4)K inhibitor KDU691 selectively inhibits dihydroartemisinin-pretreated Plasmodium falciparum ring-stage parasites

بواسطة Dembele, L, Ang, X, Chavchich, M, Bonamy, G.M.C, Selva, J.J, Lim, M.Y.-X, Bodenreider, C, Yeung, B.K.S, Nosten, F, Russell, B.M, Edstein, M.D, Straimer, J, Fidock, D.A, Diagana, T.T, Bifani, P
منشور في 2020

The plasmodium liver-specific protein 2 (LISP2) is an early marker of liver stage development

بواسطة Devendra Kumar Gupta, Laurent Dembele, Annemarie Voorberg-Van Der Wel, Guglielmo Roma, Andy Yip, Vorada Chuenchob, Niwat Kangwanrangsan, Tomoko Ishino, Ashley M. Vaughan, Stefan H. Kappe, Erika L. Flannery, Jetsumon Sattabongko, Sebastian Mikolajczak, Pablo Bifani, Clemens H.M. Kocken, Thierry Tidiane Diagana
منشور في 2020

Antimalarial activity of KAF156 in falciparum and vivax malaria

بواسطة Nicholas J. White, Tran T. Duong, Chirapong Uthaisin, Fran'ois Nosten, Aung P. Phyo, Borimas Hanboonkunupakarn, Sasithon Pukrittayakamee, Podjanee Jittamala, Kittiphum Chuthasmit, Ming S. Cheung, Yiyan Feng, Ruobing Li, Baldur Magnusson, Marc Sultan, Daniela Wieser, Xiaolei Xun, Rong Zhao, Thierry T. Diagana, Peter Pertel, F. Joel Leong
منشور في 2018

Hepatic spheroids used as an in vitro model to study malaria relapse

بواسطة Adeline C.Y. Chua, Abhishek Ananthanarayanan, Jessica Jie Ying Ong, Jen Yi Wong, Andy Yip, Nisha Hari Singh, Yinghua Qu, Laurent Dembele, Michael McMillian, Ratawan Ubalee, Silas Davidson, Anchalee Tungtaeng, Rawiwan Imerbsin, Kapish Gupta, Chiara Andolina, Fan Lee, Kevin S-W Tan, François Nosten, Bruce Russell, Amber Lange, Thierry T. Diagana, Laurent Rénia, Bryan K.S. Yeung, Hanry Yu, Pablo Bifani
منشور في 2020

UDP-galactose and acetyl-CoA transporters as Plasmodium multidrug resistance genes

بواسطة Lim, Michelle Yi-Xiu, LaMonte, Gregory, Lee, Marcus CS, Reimer, Christin, Tan, Bee Huat, Corey, Victoria, Tjahjadi, Bianca F, Chua, Adeline, Nachon, Marie, Wintjens, Rene, Gedeck, Peter, Malleret, Benoit, Renia, Laurent, Bonamy, Ghislain MC, Ho, Paul Chi-Lui, Yeung, Bryan KS, Chow, Eric D, Lim, Liting, Fidock, David A, Diagana, Thierry T, Winzeler, Elizabeth A, Bifani, Pablo
منشور في 2022

Hepatic spheroids used as an in vitro model to study malaria relapse

بواسطة Chua, Adeline CY, Ananthanarayanan, Abhishek, Ong, Jessica Jie Ying, Wong, Jen Yi, Yip, Andy, Singh, Nisha Hari, Qu, Yinghua, Dembele, Laurent, McMillian, Michael, Ubalee, Ratawan, Davidson, Silas, Tungtaeng, Anchalee, Imerbsin, Rawiwan, Gupta, Kapish, Andolina, Chiara, Lee, Fan, Tan, Kevin S-W, Nosten, Francois, Russell, Bruce, Lange, Amber, Diagana, Thierry T, Renia, Laurent, Yeung, Bryan KS, Yu, Hanry, Bifani, Pablo
منشور في 2020

Direct inhibitors of InhA are active against Mycobacterium tuberculosis

بواسطة Manjunatha, Ujjini Havaldar, Rao, Srinivasa P S, Kondreddi, Ravinder Reddy Eddy, Noble, Christian G, Camacho, Luis Reinaldo, Tan, Bee H, Ng, Seowhwee, Ng, Pearlyshuyi, Ma, Ng L, Lakshminarayana, Suresh B., Herve, Maxime R., Barnes, Susan W, Yu, Weixuan, Kuhen, Kelli L, Blasco, Francesca, Beer, David, Walker, John R, Tonge, Peter J, Glynne, Richard J, Smith, Paul W, Diagana, Thierry Tidiane
منشور في 2016

Transcriptomic analysis reveals reduced transcriptional activity in the malaria parasite Plasmodium cynomolgi during progression into dormancy

بواسطة Nicole L. Bertschi, Annemarie Voorberg-Van der Wel, Anne Marie Zeeman, Sven Schuierer, Florian Nigsch, Walter Carbone, Judith Knehr, Devendra K. Gupta, Sam O. Hofman, Nicole van der Werff, Ivonne Nieuwenhuis, Els Klooster, Bart W. Faber, Erika L. Flannery, Sebastian A. Mikolajczak, Vorada Chuenchob, Binesh Shrestha, Martin Beibel, Tewis Bouwmeester, Niwat Kangwanrangsan, Jetsumon Sattabongkot, Thierry T. Diagana, Clemens H.M. Kocken, Guglielmo Roma
منشور في 2019

Spiroindolones, a potent compound class for the treatment of malaria

بواسطة Matthias Rottmann, Case McNamara, Bryan K.S. Yeung, Marcus C.S. Lee, Bin Zou, Bruce Russell, Patrick Seitz, David M. Plouffe, Neekesh V. Dharia, Jocelyn Tan, Steven B. Cohen, Kathryn R. Spencer, Gonzalo E. González-Páez, Suresh B. Lakshminarayana, Anne Goh, Rossarin Suwanarusk, Timothy Jegla, Esther K. Schmitt, Hans Peter Beck, Reto Brun, Francois Nosten, Laurent Renia, Veronique Dartois, Thomas H. Keller, David A. Fidock, Elizabeth A. Winzeler, Thierry T. Diagana
منشور في 2018

KAI407, a potent non-8-aminoquinoline compound that kills Plasmodium cynomolgi early dormant liver stage parasites in vitro

بواسطة Zeeman, A.-M, Van Amsterdam, S.M, McNamara, C.W, Voorberg-van Der Wel, A, Klooster, E.J, Van Den Berg, A, Remarque, E.J, Plouffe, D.M, Van Gemert, G.-J, Luty, A, Sauerwein, R, Gagaring, K, Borboa, R, Chen, Z, Kuhen, K, Glynne, R.J, Chatterjee, A.K, Nagle, A, Roland, J, Winzeler, E.A, Leroy, D, Campo, B, Diagana, T.T, Yeung, B.K.S, Thomas, A.W, Kocken, C.H.M
منشور في 2020

Robust continuous in vitro culture of the Plasmodium cynomolgi erythrocytic stages

بواسطة Chua, A.C.Y., Ong, J.J.Y., Malleret, B., Suwanarusk, R., Kosaisavee, V., Zeeman, A.-M., Cooper, C.A., Tan, K.S.W., Zhang, R., Tan, B.H., Abas, S.N., Yip, A., Elliot, A., Joyner, C.J., Cho, J.S., Breyer, K., Baran, S., Lange, A., Maher, S.P., Nosten, F., Bodenreider, C., Yeung, B.K.S., Mazier, D., Galinski, M.R., Dereuddre-Bosquet, N., Le Grand, R., Kocken, C.H.M., Rénia, L., Kyle, D.E., Diagana, T.T., Snounou, G., Russell, B., Bifani, P.
منشور في 2021

Robust continuous in vitro culture of the Plasmodium cynomolgi erythrocytic stages

بواسطة Adeline C.Y. Chua, Jessica Jie Ying Ong, Benoit Malleret, Rossarin Suwanarusk, Varakorn Kosaisavee, Anne Marie Zeeman, Caitlin A. Cooper, Kevin S.W. Tan, Rou Zhang, Bee Huat Tan, Siti Nurdiana Abas, Andy Yip, Anne Elliot, Chester J. Joyner, Jee Sun Cho, Kate Breyer, Szczepan Baran, Amber Lange, Steven P. Maher, François Nosten, Christophe Bodenreider, Bryan K.S. Yeung, Dominique Mazier, Mary R. Galinski, Nathalie Dereuddre-Bosquet, Roger Le Grand, Clemens H.M. Kocken, Laurent Rénia, Dennis E. Kyle, Thierry T. Diagana, Georges Snounou, Bruce Russell, Pablo Bifani
منشور في 2020