Elucidating antibiotic permeation through the Escherichia coli outer membrane: insights from molecular dynamics

by Deylami, Javad, Chng, Shu Sin, Yong, Ee Hou
Published 2025

Defining key roles for auxiliary proteins in an ABC transporter that maintains bacterial outer membrane lipid asymmetry

by Thong, Shuhua, Ercan, Bilge, Torte, Federico, Fong, Zhen Yang, Wong, Hui Yi Alvina, Wenk, Markus R, Chng, Shu-Sin
Published 2020

Novel acetamide indirectly targets mycobacterial transporter MmpL3 by proton motive force disruption

by Shetty, Annanya, Xu, Zhujun, Lakshmanan, Umayal, Hill, Jeffrey, Choong, Meng Ling, Chng, Shu-Sin, Yamada, Yoshiyuki, Poulsen, Anders, Dick, Thomas, Gengenbacher, Martin
Published 2019

Potency Increase of Spiroketal Analogs of Membrane Inserting Indolyl Mannich Base Antimycobacterials Is Due to Acquisition of MmpL3 Inhibition.

by Li, Ming, Phua, Zheng Yen, Xi, Yu, Xu, Zhujun, Nyantakyi, Samuel Agyei, Li, Wei, Jackson, Mary C, Wong, Ming Wah, Lam, Yulin, Chng, Shu-Sin, Go, Mei-Lin, Dick, Thomas
Published 2020

Depleting cationic lipids involved in antimicrobial resistance drives adaptive lipid remodeling in Enterococcus faecalis

by Rashid, Rafi, Nair, Zeus J., Chia, Dominic Ming Hao, Chong, Kelvin Kian Long, Cazenave Gassiot, Amaury, Morley, Stewart A., Allen, Doug K., Chen, Swaine L., Chng, Shu-Sin, Wenk, Markus R., Kline, Kimberly A.
Published 2023

Depleting Cationic Lipids Involved in Antimicrobial Resistance Drives Adaptive Lipid Remodeling in Enterococcus faecalis

by Rashid, Rafi, Nair, Zeus Jaren, Chia, Dominic Ming Hao, Chong, Kelvin Kian Long, Gassiot, Amaury Cazenave, Morley, Stewart A, Allen, Doug K, Chen, Swaine L, Chng, Shu Sin, Wenk, Markus R, Kline, Kimberly A
Published 2023

Structure-function characterization of the conserved regulatory mechanism of the Escherichia coli M48 metalloprotease BepA

by Bryant, Jack A., Cadby, Ian T., Chong, Zhi-Soon, Boelter, Gabriela, Sevastsyanovich, Yanina R., Morris, Faye C., Cunningham, Adam F., Kritikos, George, Meek, Richard W., Banzhaf, Manuel, Chng, Shu-Sin, Lovering, Andrew L., Henderson, Ian R.
Published 2022

Loss of YhcB results in dysregulation of coordinated peptidoglycan, LPS and phospholipid synthesis during Escherichia coli cell growth

by Goodall, Emily C. A., Isom, Georgia L., Rooke, Jessica L., Pullela, Karthik, Icke, Christopher, Yang, Zihao, Boelter, Gabriela, Jones, Alun, Warner, Isabel, Da Costa, Rochelle, Zhang, Bing, Rae, James, Tan, Wee Boon, Winkle, Matthias, Delhaye, Antoine, Heinz, Eva, Collet, Jean-Francois, Cunningham, Adam F., Blaskovich, Mark A., Parton, Robert G., Cole, Jeff A., Banzhaf, Manuel, Chng, Shu-Sin, Vollmer, Waldemar, Bryant, Jack A., Henderson, Ian R.
Published 2022