Improved eIF4E Binding Peptides by Phage Display Guided Design: Plasticity of Interacting Surfaces Yield Collective Effects

by Zhou, W., Quah, S.T., Verma, C.S., Liu, Y., Lane, D.P., Brown, C.J.
Published 2014

C-terminal Substitution of MDM2 interacting peptides modulates binding affinity by distinctive mechanisms

by Brown, C.J., Dastidar, S.G., Quah, S.T., Lim, A., Chia, B., Verma, C.S.
Published 2014

Rational optimization of conformational effects induced by hydrocarbon staples in peptides and their binding interfaces

by Lama, D., Quah, S.T., Verma, C.S., Lakshminarayanan, R., Beuerman, R.W., Lane, D.P., Brown, C.J.
Published 2014

Global trends in mangrove forest fragmentation

by Bryan-Brown, D.N., Connolly, R.M., Richards, D.R., Adame, F., Friess, D.A., Brown, C.J.
Published 2021

Structural insights reveal a recognition feature for tailoring hydrocarbon stapled-peptides against the eukaryotic translation initiation factor 4E protein

by Lama, D., Liberatore, A.-M., Frosi, Y., Nakhle, J., Tsomaia, N., Bashir, T., Lane, D.P., Brown, C.J., Verma, C.S., Auvin, S.
Published 2021

Molecular rotors as conditionally fluorescent labels for rapid detection of biomolecular interactions

by Goh, W.L., Lee, M.Y., Joseph, T.L., Quah, S.T., Brown, C.J., Verma, C., Brenner, S., Ghadessy, F.J., Teo, Y.N.
Published 2014

Enhancing specific disruption of intracellular protein complexes by hydrocarbon stapled peptides using lipid based delivery

by Thean, D, Ebo, J.S, Luxton, T, Lee, X.C, Yuen, T.Y, Ferrer, F.J, Johannes, C.W, Lane, D.P, Brown, C.J
Published 2020

Structure-activity studies of Mdm2/Mdm4-binding stapled peptides comprising non-natural amino acids

by Chee S.M.Q., Wongsantichon J., Siau J., Thean D., Ferrer F., Robinson R.C., Lane D.P., Brown C.J., Ghadessy F.J.
Published 2019

Structure of a stapled peptide antagonist bound to nutlin-resistant Mdm2

by Chee S.M.Q., Wongsantichon J., Soo Tng Q., Robinson R., Joseph T.L., Verma C., Lane D.P., Brown C.J., Ghadessy F.J.
Published 2019

Assessing the Efficacy of Mdm2/Mdm4-Inhibiting Stapled Peptides Using Cellular Thermal Shift Assays

by Xiong Tan, B, Brown, C.J, Ferrer, F.J, Yuen, T.Y, Quah, S.T, Chan, B.H, Jansson, A.E, Teo, H.L, Nordlund, P, Lane, D.P
Published 2020

Role of IncP-1β plasmids pWDL7

by Król, J. E., Penrod, J. T., McCaslin, H., Rogers, L. M., Yano, H., Stancik, A. D., Dejonghe, W., Brown, C. J., Parales, R. E., Wuertz, Stefan., Top, E. M.
Published 2013

Stapled peptides with improved potency and specificity that activate p53

by Brown, C.J., Quah, S.T., Jong, J., Goh, A.M., Chiam, P.C., Khoo, K.H., Choong, M.L., Lee, M.A., Yurlova, L., Zolghadr, K., Joseph, T.L., Verma, C.S., Lane, D.P.
Published 2014

Functionalised staple linkages for modulating the cellular activity of stapled peptides

by Lau, Y.H., De Andrade, P., Quah, S.-T., Rossmann, M., Laraia, L., Sköld, N., Sum, T.J., Rowling, P.J.E., Joseph, T.L., Verma, C., Hyvönen, M., Itzhaki, L.S., Venkitaraman, A.R., Brown, C.J., Lane, D.P., Spring, D.R.
Published 2014

Benzene Probes in Molecular Dynamics Simulations Reveal Novel Binding Sites for Ligand Design

by Tan, Y.S, Reeks, J, Brown, C.J, Thean, D, Ferrer Gago, F.J, Yuen, T.Y, Goh, E.T.L, Lee, X.E.C, Jennings, C.E, Joseph, T.L, Lakshminarayanan, R, Lane, D.P, Noble, M.E.M, Verma, C.S
Published 2020

Macrocyclization of an all-dlinear α-helical peptide imparts cellular permeability

by Kannan, S., Aronica, P.G.A., Ng, S., Gek Lian, D.T., Frosi, Y., Chee, S., Shimin, J., Yuen, T.Y., Sadruddin, A., Kaan, H.Y.K., Chandramohan, A., Wong, J.H., Tan, Y.S., Chang, Z.W., Ferrer-Gago, F.J., Arumugam, P., Han, Y., Chen, S., Rénia, L., Brown, C.J., Johannes, C.W., Henry, B., Lane, D.P., Sawyer, T.K., Verma, C.S., Partridge, A.W.
Published 2021