Increased phagocytosis of Plasmodium falciparum-infected erythrocytes with haemoglobin E by peripheral blood monocytes

• المؤلفون الرئيسيون: Ahnond Bunyaratvej, Punnee Butthep, Yongyuth Yuthavong, Suthat Fucharoen, Srisin Khusmith, Sutee Yoksan, Prawase Wasi
• مؤلفون آخرون: Faculty of Medicine, Ramathibodi Hospital, Mahidol University
• التنسيق: مقال
• منشور في: 2018
• الموضوعات: Medicine
• الوصول للمادة أونلاين: https://repository.li.mahidol.ac.th/handle/123456789/9854

Erythrocytes from subjects with homozygous and heterozygous haemoglobin E (HbE) infected with Plasmodium falciparum in vitro were phagocytosed to a greater extent by normal human monocytes than infected erythrocytes from normal subjects. Susceptibility to phagocytosis was maximal when the parasites developed to trophozoite and schizont stages in both normal and patients' erythrocytes. The increased susceptibility of P. falciparum-infected HbE erythrocytes to phagocytosis by monocytes may play a role in protection against malaria. © 1986 S. Karger AG, Basel.