Production of human embryonic kidney 293T cells stably expressing C-X-C chemokine receptor type 4 (CXCR4) as a screening tool for anticancer lead compound targeting CXCR4

• Main Authors: Dinh Thi Thai Ha, Kittirat Glab-ampai, Pornchai Rojsitthisak, Opa Vajragupta
• 其他作者: Siriraj Hospital
• 格式: Article
• 出版: 2022
• 主題: Biochemistry, Genetics and Molecular Biology; Pharmacology, Toxicology and Pharmaceutics
• 在線閱讀: https://repository.li.mahidol.ac.th/handle/123456789/73232
• 機構: Mahidol University

Aim: The C-X-C chemokine-receptor type 4 (CXCR4) is an emerging target for cancer drug discovery due to its high expression in cancer cells. The present study aimed to produce CXCR4 overexpressing HEK293T cells for a non-radioactive binding assay as a platform to identify drug candidates targeting C...