Global gene expression profiling of Plasmodium falciparum in response to the anti-malarial drug pyronaridine

• Main Authors: Kanyanan Kritsiriwuthinan, กัญญนันทน์ กฤษศิริวุฒินันท์, Sastra Chaotheing, Shaw, Philip J., Chayaphat Wongsombat, Porntip Chavalitshewinkoon-Petmitr, พรทิพย์ เพ็ชรมิตร, Sumalee Kamchonwongpaisan, สุมาลี กำจรวงศ์ไพศาล
• Format: Article
• Language: English
• Published: 2012
• Subjects: Chloroquine; Gene expression; Microarray; Plasmodium falciparum; Pyronaridine; Open Access article
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/730

BACKGROUND: Pyronaridine (PN) and chloroquine (CQ) are structurally related anti-malarial drugs with primarily the same mode of action. However, PN is effective against several multidrug-resistant lines of Plasmodium falciparum, including CQ resistant lines, suggestive of important operational di...