Nucleophilic trifluoromethylation of anhydrides employing (trifluoromethyl)trimethylsilane: Synthesis of γ-trifluoromethylated γ-butyrolactones
Fluoride-catalyzed nucleophilic trifluoromethylation of acid anhydrides using CF3SiMe3 provided the corresponding γ-hydroxy-γ- trifluoromethyl-γ-butyrolactones. The utility of these adducts was further demonstrated by treatment with Grignard reagents, leading to γ-trifluoromethylated γ-butyrolactone...
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| Main Authors: | , , , , , |
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| 格式: | Article |
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2018
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| 在線閱讀: | https://repository.li.mahidol.ac.th/handle/123456789/31389 |
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| 機構: | Mahidol University |
| 總結: | Fluoride-catalyzed nucleophilic trifluoromethylation of acid anhydrides using CF3SiMe3 provided the corresponding γ-hydroxy-γ- trifluoromethyl-γ-butyrolactones. The utility of these adducts was further demonstrated by treatment with Grignard reagents, leading to γ-trifluoromethylated γ-butyrolactones. © 2013 Elsevier B.V. All rights reserved. |
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