Survey of innate immune responses to Burkholderia pseudomallei in human blood identifies a central role for lipopolysaccharide

• Main Authors: Narisara Chantratita, Sarunporn Tandhavanant, Nicolle D. Myers, Sudeshna Seal, Arkhom Arayawichanont, Aroonsri Kliangsa-ad, Lauren E. Hittle, Robert K. Ernst, Mary J. Emond, Mark M. Wurfel, Nicholas P.J. Day, Sharon J. Peacock, T. Eoin West
• Other Authors: Mahidol University
• Format: Article
• Published: 2018
• Subjects: Agricultural and Biological Sciences; Biochemistry, Genetics and Molecular Biology
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/30948

B. pseudomallei is a gram-negative bacterium that causes the tropical infection melioidosis. In northeast Thailand, mortality from melioidosis approaches 40%. As exemplified by the lipopolysaccharide-Toll-like receptor 4 interaction, innate immune responses to invading bacteria are precipitated by a...