Urokinase receptor is necessary for bacterial defense against pneumonia-derived septic melioidosis by facilitating phagocytosis

• Main Authors: W. Joost Wiersinga, Liesbeth M. Kager, Joppe W.R. Hovius, Gerritje J.W. Van Der Windt, Alex F. De Vos, Joost C.M. Meijers, Joris J. Roelofs, Arjen Dondorp, Marcel Levi, Nicholas P. Day, Sharon J. Peacock, Tom Van Der Poll
• Other Authors: Academic Medical Centre, University of Amsterdam
• Format: Article
• Published: 2018
• Subjects: Immunology and Microbiology
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/29250
• Institution: Mahidol University

Urokinase receptor (urokinase-type plasminogen activator receptor [uPAR], CD87), a GPI-anchored protein, is considered to play an important role in inflammation and fibrinolysis. The Gram-negative bacterium Burkholderia pseudomallei is able to survive and replicate within leukocytes and causes melio...