A phase III, randomized, non-inferiority trial to assess the efficacy and safety of dihydroartemisinin-piperaquine in comparison with artesunate- mefloquine in patients with uncomplicated Plasmodium falciparum Malaria in Southern Laos

• Main Authors: Mayfong Mayxay, Sommay Keomany, Maniphone Khanthavong, Phoutthalavanh Souvannasing, Kasia Stepniewska, Tiengthong Khomthilath, Siamphay Keola, Tiengkham Pongvongsa, Samlane Phompida, David Ubben, Neena Valecha, Nicholas J. White, Paul N. Newton
• 其他作者: Mahosot Hospital
• 格式: Article
• 出版: 2018
• 主題: Immunology and Microbiology; Medicine
• 在線閱讀: https://repository.li.mahidol.ac.th/handle/123456789/29171

We conducted an open, randomized clinical trial of oral dihydroartemisinin-piperaquine (DP) versus artesunate-mefloquine (AM) in 300 patients in Laos with uncomplicated Plasmodium falciparum malaria as part of a multicentre study in Asia. Survival analysis and adjustment for re-infection showed that...