Angiotensin-converting enzyme is a modifier of hypertensive end organ damage

• Main Authors: Xiaojun Liu, Christopher O.C. Bellamy, Matthew A. Bailey, Linda J. Mullins, Donald R. Dunbar, Christopher J. Kenyon, Gillian Brooker, Surasak Kantachuvesiri, Klio Maratou, Ali Ashek, Allan F. Clark, Stewart Fleming, John J. Mullins
• Other Authors: University of Edinburgh
• Format: Article
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/27202
• Institution: Mahidol University

Severe forms of hypertension are characterized by high blood pressure combined with end organ damage. Through the development and refinement of a transgenic rat model of malignant hypertension incorporating the mouse renin gene, we previously identified a quantitative trait locus on chromosome 10, w...