Cytotoxic mycoepoxydiene derivatives from an endophytic fungus Phomopsis sp. isolated from Hydnocarpus anthelminthicus

• Main Authors: Surasak Prachya, Suthep Wiyakrutta, Nongluksna Sriubolmas, Nattaya Ngamrojanavanich, Chulabhorn Mahidol, Somsak Ruchirawat, Prasat Kittakoop
• Other Authors: Chulabhorn Research Institute
• Format: Article
• Published: 2018
• Subjects: Agricultural and Biological Sciences; Chemistry; Pharmacology, Toxicology and Pharmaceutics
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/23975

Mycoepoxydiene (1) and derivatives, deacetylmycoepoxydiene (2) and 2,3-dihydromycoepoxydiene (3), were isolated from a broth extract of the endophytic fungus, Phomopsis sp., which was isolated from a Thai medicinal plant, Hydnocarpus anthelminthicus. Compounds 1 and 2 exhibited potent cytotoxic acti...