Limited diagnostic capacities of two commercial assays for the detection of Leptospira immunoglobulin M antibodies in Laos

• المؤلفون الرئيسيون: Stuart D. Blacksell, Lee Smythe, Rattanaphone Phetsouvanh, Michael Dohnt, Rudy Hartskeerl, Meegan Symonds, Andrew Slack, Manivanh Vongsouvath, Viengmone Davong, Olay Lattana, Simmaly Phongmany, Valy Keolouangkot, Nicholas J. White, Nicholas P.J. Day, Paul N. Newton
• مؤلفون آخرون: Mahosot Hospital
• التنسيق: مقال
• منشور في: 2018
• الموضوعات: Biochemistry, Genetics and Molecular Biology; Immunology and Microbiology; Medicine
• الوصول للمادة أونلاين: https://repository.li.mahidol.ac.th/handle/123456789/22973

The diagnostic utility of immunochromatographic (Leptotek) and enzyme-linked immunosorbent assay (ELISA; Panbio) tests for the detection of Leptospira immunoglobulin M antibodies was assessed in febrile adults admitted in Vientiane, Laos. Both tests demonstrated poor diagnostic accuracy using admission serum (Leptotek sensitivity of 47.3% and specificity of 75.5%: ELISA sensitivity of 60.9% and specificity of 65.6%) compared to the Leptospira "gold standard" microscopic agglutination test. Copyright © 2006, American Society for Microbiology. All Rights Reserved.