Limited diagnostic capacities of two commercial assays for the detection of Leptospira immunoglobulin M antibodies in Laos

Limited diagnostic capacities of two commercial assays for the detection of Leptospira immunoglobulin M antibodies in Laos

The diagnostic utility of immunochromatographic (Leptotek) and enzyme-linked immunosorbent assay (ELISA; Panbio) tests for the detection of Leptospira immunoglobulin M antibodies was assessed in febrile adults admitted in Vientiane, Laos. Both tests demonstrated poor diagnostic accuracy using admiss...

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Bibliographic Details
Main Authors: Stuart D. Blacksell, Lee Smythe, Rattanaphone Phetsouvanh, Michael Dohnt, Rudy Hartskeerl, Meegan Symonds, Andrew Slack, Manivanh Vongsouvath, Viengmone Davong, Olay Lattana, Simmaly Phongmany, Valy Keolouangkot, Nicholas J. White, Nicholas P.J. Day, Paul N. Newton
Other Authors: Mahosot Hospital
Format: Article
Published: 2018
Subjects:
Biochemistry, Genetics and Molecular Biology
Immunology and Microbiology
Medicine
Online Access:https://repository.li.mahidol.ac.th/handle/123456789/22973
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Summary:The diagnostic utility of immunochromatographic (Leptotek) and enzyme-linked immunosorbent assay (ELISA; Panbio) tests for the detection of Leptospira immunoglobulin M antibodies was assessed in febrile adults admitted in Vientiane, Laos. Both tests demonstrated poor diagnostic accuracy using admission serum (Leptotek sensitivity of 47.3% and specificity of 75.5%: ELISA sensitivity of 60.9% and specificity of 65.6%) compared to the Leptospira "gold standard" microscopic agglutination test. Copyright © 2006, American Society for Microbiology. All Rights Reserved.

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