Activation of α-secretase by curcumin-aminoacid conjugates

• Main Authors: Ramesh B. Narasingapa, Manjunatha R. Jargaval, Srinivas Pullabhatla, Htut Htut Htoo, Jagannatha K.S. Rao, Jean François Hernandez, Piyarat Govitrapong, Bruno Vincent
• Other Authors: Mahidol University
• Format: Article
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/13640

The extracellular senile plaques observed in Alzheimer's disease (AD) patients are mainly composed of amyloid peptides produced from the β-amyloid precursor protein (βAPP) by β- and γ-secretases. A third non-amyloidogenic α-secretase activity performed by the disintegrins ADAM10 and ADAM17 occu...