Systematic study on genetic and epimutational profile of a cohort of amsterdam criteria-defined lynch syndrome in Singapore

• Main Authors: Liu Y., Chew M.H., Goh X.W., Tan S.Y., Loi C.T.T., Tan Y.M., Law H.Y., Koh P.K., Tang C.L.
• 其他作者: NUSHS PROJECT
• 格式: Article
• 出版: 2019
• 主題: adult; aged; article; controlled study; DNA sequence; epigenetics; ethnicity; female; gene; gene deletion; gene duplication; gene expression profiling; gene identification; gene mutation; genetic analysis; genetic screening; genotype phenotype correlation; germ line; hereditary nonpolyposis colorectal cancer; human; human tissue; immunohistochemistry; major clinical study; male; methylation; microsatellite instability; mismatch repair; MLH1 gene; molecular diagnosis; MSH2 gene; MSH6 gene; multiplex ligation dependent probe amplification; mutational analysis; PMS2 gene; Singapore; very elderly; young adult; cohort analysis; genetics; genotype; middle aged; mutation; phenotype; systems biology; Adult; Aged; Aged, 80 and over; Cohort Studies; Colorectal Neoplasms, Hereditary Nonpolyposis; DNA Mismatch Repair; Epigenomics; Female; Genotype; Humans; Male; Middle Aged; Mutation; Phenotype; Systems Biology; Young Adult
• 在線閱讀: https://scholarbank.nus.edu.sg/handle/10635/161419

10.1371/journal.pone.0094170