A tail-based mechanism drives nucleosome demethylation by the LSD2/NPAC multimeric complex

• المؤلفون الرئيسيون: Marabelli, Chiara, Marrocco, Biagina, Pilotto, Simona, Chittori, Sagar, Picaud, Sarah, Marchese, Sara, Ciossani, Giuseppe, Forneris, Federico, Filippakopoulos, Panagis, Schoehn, Guy, Rhodes, Daniela, Subramaniam, Sriram, Mattevi, Andrea
• مؤلفون آخرون: School of Biological Sciences
• التنسيق: مقال
• اللغة: English
• منشور في: 2019
• الموضوعات: Histone Demethylation; Cryoelectron Microscopy; DRNTU::Science::Biological sciences
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/93135; http://hdl.handle.net/10220/48524
• المؤسسة: Nanyang Technological University

LSD1 and LSD2 are homologous histone demethylases with opposite biological outcomes related to chromatin silencing and transcription elongation, respectively. Unlike LSD1, LSD2 nucleosome-demethylase activity relies on a specific linker peptide from the multidomain protein NPAC. We used single-parti...