The uniqueness of subunit α of mycobacterial F-ATP synthases: An evolutionary variant for niche adaptation

• المؤلفون الرئيسيون: Ragunathan, Priya, Sielaff, Hendrik, Sundararaman, Lavanya, Biuković, Goran, Subramanian Manimekalai, Malathy Sony, Singh, Dhirendra, Kundu, Subhashri, Wohland, Thorsten, Frasch, Wayne, Dick, Thomas, Grüber, Gerhard
• مؤلفون آخرون: School of Biological Sciences
• التنسيق: مقال
• اللغة: English
• منشور في: 2018
• الموضوعات: ATP Synthase; Bioenergetics
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/87064; http://hdl.handle.net/10220/44250

The F1F0 -ATP (F-ATP) synthase is essential for growth of Mycobacterium tuberculosis, the causative agent of tuberculosis (TB). In addition to their synthase function most F-ATP synthases possess an ATP-hydrolase activity, which is coupled to proton-pumping activity. However, the mycobacterial enzym...