Targeting adenosine-2 B receptor : a potential metabolic immune checkpoint

• المؤلف الرئيسي: Tay, Hui Min
• مؤلفون آخرون: Andreas Lundqvist
• التنسيق: Final Year Project
• اللغة: English
• منشور في: 2019
• الموضوعات: DRNTU::Science::Biological sciences
• الوصول للمادة أونلاين: http://hdl.handle.net/10356/77108

Adenosine is an anti-inflammatory and immunosuppressive metabolite that binds to the adenosine receptors (AR) - A1R, A2AR, A2BR and A3R. Adenosine immunosuppression is mediated via A2Rs, with A2BR only activated by high adenosine concentration such as within solid tumor microenvironments (TME). A...