Structural insights into viral RNA capping and plasma membrane targeting by Chikungunya virus nonstructural protein 1

• المؤلفون الرئيسيون: Zhang, Kuo, Law, Yee-Song, Law, Michelle Cheok Yien, Tan, Yaw Bia, Wirawan, Melissa, Luo, Dahai
• مؤلفون آخرون: School of Biological Sciences
• التنسيق: مقال
• اللغة: English
• منشور في: 2022
• الموضوعات: Science::Biological sciences; Chikungunya Virus; RNA Cap
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/157046
• المؤسسة: Nanyang Technological University

Chikungunya virus (CHIKV) causes a debilitating arthralgic inflammatory disease in humans. The multifunctional CHIKV protein, nsP1, facilitates virus RNA replication and transcription by anchoring the viral replication complex (RC) to plasma membrane vesicles and synthesizing the viral RNA 5' c...