Asymmetric Michael addition of 5 H-oxazol-4-ones to vinyl sulfones : stereoselective synthesis of monofluorinated analogs of 2-tertiary hydroxyl-3-methyl-substituted carboxylic acidl derivatives

• Main Authors: Liu, Qian, Qiao, Baokun, Chin, Kek Foo, Tan, Choon-Hong, Jiang, Zhiyong
• 其他作者: School of Physical and Mathematical Sciences
• 格式: Article
• 語言: English
• 出版: 2015
• 主題: DRNTU::Science::Chemistry::Physical chemistry::Catalysis
• 在線閱讀: https://hdl.handle.net/10356/106585; http://hdl.handle.net/10220/25011; http://dx.doi.org/10.1002/adsc.201400649
• 機構: Nanyang Technological University

An asymmetric Michael addition of 5H-oxazol-4-ones to vinyl sulfones has been developed. In the presence of 10 mol % of quinine-based benzyl-substituted thiourea as catalyst at 0 °C, the products could be obtained with excellent enantio- and diastereoselectivity (up to>99 % ee and>20:1 dr). 1....