Organocatalytic enantioselective γ-aminoalkylation of unsaturated ester : access to pipecolic acid derivatives

• المؤلفون الرئيسيون: Xu, Jianfeng, Jin, Zhichao, Chi, Robin Yonggui
• مؤلفون آخرون: School of Physical and Mathematical Sciences
• التنسيق: مقال
• اللغة: English
• منشور في: 2014
• الموضوعات: DRNTU::Science::Chemistry::Organic chemistry
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/104212; http://hdl.handle.net/10220/19439
• المؤسسة: Nanyang Technological University

The direct γ-carbon functionalization of α,β-unsaturated esters via N-Heterocyclic Carbene (NHC) catalysis is disclosed. This catalytically generated nucleophilic γ-carbon undergoes highly enantioselective additions to hydrazones. The resulting δ-lactam products can be readily transformed to optical...