Biosynthesis of A6'7-anhydroerythromycin via enoyl reductase inhibition by isonicotinic hydrazide (INH)

• المؤلف الرئيسي: Perpustakaan UGM, i-lib
• التنسيق: مقال NonPeerReviewed
• منشور في: [Yogyakarta] : Universitas Gadjah Mada 1999
• الموضوعات: Jurnal i-lib UGM
• الوصول للمادة أونلاين: https://repository.ugm.ac.id/17856/; http://i-lib.ugm.ac.id/jurnal/download.php?dataId=624
• المؤسسة: Universitas Gadjah Mada

Isonicotinic hydrazide (INH) was added to a fermentation of mutant of Saccharopolyspora erythraea ATCC 11912 to inhibit the activity of 2,4,6,8-tetramethyI-7,9-dihydroxy-2-en-5-on-undecyl-ACP enoyl reductase, an enzyme which catalyses enoyl reduction process of an intermediate in the erythronolide b...