PREPARATION OF ACYCLOVIR-NICOTINAMIDE COCRYSTAL BY SOLVENT EVAPORATION TECHNIQUE WITH VARIATION OF SOLVENT

• Main Authors: NAWATILA, ROISAH, NUNIEK W, AGNES, SISWODIHARDJO, SISWANDONO, SETYAWAN D, DWI
• 格式: Article PeerReviewed
• 語言: English; English
• 出版: 2017
• 主題: RS Pharmacy and materia medica; RS1-441 Pharmacy and materia medica; RS200-201 Pharmaceutical dosage forms
• 在線閱讀: http://repository.unair.ac.id/75756/1/C-14%20Artikel.pdf; http://repository.unair.ac.id/75756/2/C-14%20Validasi%20dan%20Peer%20Reviewer.pdf; http://repository.unair.ac.id/75756/
• 機構: Universitas Airlangga

Objective: This research aims to prepare cocrystal of acyclovir (ACV)-nicotinamide (NCT) by solvent evaporation with a variation of solvent (ethanol, glacial acetic acid, and HCl 0.1 N) to improve the bioavailability of ACV as an antiviral drug. Methods: Cocrystal were developed by solvent evapora...