PHYSICAL INTERACTION STUDY OF IBUPROFEN-STEARIC ACID BINARY MIXTURE
Ibuprofen is a non steroid anti-inflammatory drug (NSAID) derived from propionic acid [3]. It has low aqueous solubility but high permeability so it is classified into BCS (Biopharmaceutical Classification System) Class II [6]. High cohesivity and adhesivity cause ibuprofen has b...
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| 格式: | Conference or Workshop Item PeerReviewed |
| 語言: | English English |
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2014
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| 主題: | |
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| 總結: | Ibuprofen is a non steroid anti-inflammatory
drug (NSAID) derived from propionic acid [3].
It has low aqueous solubility but high permeability
so it is classified into BCS (Biopharmaceutical
Classification
System)
Class
II
[6].
High
cohesivity
and
adhesivity
cause
ibuprofen
has
bad
powder flow and also contributes to its
high tendency for sticking to the punch. Granulation
step
is
necessary
in
ibuprofen
tableted
dosage
form
manufacturing
due
bad
compaction
behaviour [9]. Thus, addition of appropriate
excipients
is
hardly
avoidable
in
order
to
improve powder properties in ibuprofen
tableted dosage form formulation.
Pharmaceutical dosage form manufacturing
always involves heat and mechanical energy
during the process [10]. This energy could induce
interaction between drug and excipient
molecules [10] as well as eutectic formation.
Eutectics are intimate crystalline mixture of
one compound in another and it has unique
property in its lower melting temperature
than that pure compound. Generally, eutectic
interaction does not impact the pharmacological
activity,
but
may
contribute
in
alteration
of
the
pharmaceutical properties. Unintentional
eutectic formation in tableted dosage form development
have
been reported
to
lead
to
unwanted
changes
in the
physical
and/or
chemical
characteristics
of the tablets
[2].
Ibuprofen
is a kind of drug that
forms
eutectic
with
some
kind
of
excipients
as
reported
in
many
studies
[7, 11, 1]. It has been identified
by DSC analysis that ibuprofen forms eutectic
with stearic acid [7], one of most frequently
used lubricant [4]. Therefore, further physical
characterization was conducted in this study
for better understanding of eutectic formation
in ibuprofen-stearic acid binary system. |
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