CHITOSAN BASED PARTICULATE CARRIER OF DITERPENE LACTON OF SAMBILOTO PREPARED BY IONIC GELATION-SPRAY DRYING :EFFECT OF STIRRING RATE AND NOZZLE DIAMETER
Chitosan, a cationic polysaccharide has many advantages as carrier for drug delivery system such as biocompatible, biodegradable and non toxic.Chitosan has amino group that could be crosslinked with polianion such as tripolyphosphate so that the active ingredient will be entrapped (Agnihotr...
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| Main Authors: | , , , |
|---|---|
| Format: | Conference or Workshop Item PeerReviewed |
| Language: | English English |
| Published: |
2014
|
| Subjects: | |
| Online Access: | http://repository.unair.ac.id/75746/1/C-26%20Artikel.pdf http://repository.unair.ac.id/75746/2/C-26%20Validasi%20dan%20Peer%20Reviewer.pdf http://repository.unair.ac.id/75746/ |
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| Summary: | Chitosan, a cationic polysaccharide has many
advantages as carrier for drug delivery system
such as biocompatible, biodegradable and
non toxic.Chitosan has amino group that could
be crosslinked with polianion such as tripolyphosphate
so that the active ingredient will
be entrapped (Agnihotri, 2004, Sinha, 2004).
Diterpene lactone fraction of sambiloto (Andrographis
paniculata) has antimalarial activity
but
it
has
low
solubility
in
water.
Entrapped
diterpene
lactone
into
chitosan
matrix
could
improve
the bioavailability of the active substance.
The
aim
of
this
research
is
to
investigate
the
effect
of
process
parameter
of
chitosan
carrier
preparation
: stirring rate (500 rpm and 1000
rpm) during ionic gelation and nozzle diameter
(0.5 mm and 1.0 mm) of spray dryer on
physical characteristics of diterpene lactone
fraction-chitosan particles. Evaluation of morphology,
thermal analysis
and
drug
entrapment
were
conducted. |
|---|