การสังเคราะห์อนุพันธ์ 8-อะมิโนควิโนลีนชนิดใหม่สำหรับการตรวจวัดไอออนโลหะ
Quinoline derivatives are interesting fluorescent probes for sensing metal ions because these compounds have low initial fluorescence quantum yield and selective binding with metal ions that have strong fluorescence enhancement. In this study, a new quinoline derivative (Me2GlyAQ) is synthesized by...
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| Format: | Senior Project |
| Language: | Thai |
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จุฬาลงกรณ์มหาวิทยาลัย
2015
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| Online Access: | https://digiverse.chula.ac.th/Info/item/dc:9928 |
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| Institution: | Chulalongkorn University |
| Language: | Thai |
| Summary: | Quinoline derivatives are interesting fluorescent probes for sensing metal ions because these compounds have low initial fluorescence quantum yield and selective binding with metal ions that have strong fluorescence enhancement. In this study, a new quinoline derivative (Me2GlyAQ) is synthesized by connecting N,N-dimethylglycine on 8- aminoquinoline via an amide bond. It is characterized by ¹H NMR, ¹³C NMR and IR spectroscopy. In Tris-HCl buffer pH 7.4, this compound gives a maximum absorption and emission at 300 and 418 nm, respectively. In aqueous solution, Me2GlyAQ exhibits strong fluorescence enhancement selectively with Zn²⁺. The association constant determined by the Benesi-Hildebrand method is 2.42×10⁵ M-¹. In micromolar range, the fluorescent intensity increased linearly with the concentration of Zn²⁺ with the detection limit of 15.6 μM. Furthermore, naked eye detection of Zn²⁺ and Cd²⁺ on paper filter paper can be achieved with simple drop cast technique. |
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