Transcription factors for the modulation of pluripotency and reprogramming

by Heng, J.-C.D., Orlov, Y.L., NG, H.-H.
Published 2014

Graded Nodal/Activin signaling titrates conversion of quantitative phospho-Smad2 levels into qualitative embryonic stem cell fate decisions

by Lee, K.L., Lim, S.K., Orlov, Y.L., Yit, L.Y., Yang, H., Ang, L.T., Poellinger, L., Lim, B.
Published 2014

The Nuclear Receptor Nr5a2 Can Replace Oct4 in the Reprogramming of Murine Somatic Cells to Pluripotent Cells

by Heng, J.-C.D., Feng, B., Han, J., Jiang, J., Kraus, P., Ng, J.-H., Orlov, Y.L., Huss, M., Yang, L., Lufkin, T., Lim, B., Ng, H.-H.
Published 2014

Tbx3 improves the germ-line competency of induced pluripotent stem cells

by Han, J., Yuan, P., Yang, H., Zhang, J., Soh, B.S., Li, P., Lim, S.L., Cao, S., Tay, J., Orlov, Y.L., Lufkin, T., Ng, H.-H., Tam, W.-L., Lim, B.
Published 2014

Whole-Genome Mapping of Histone H3 Lys4 and 27 Trimethylations Reveals Distinct Genomic Compartments in Human Embryonic Stem Cells

by Zhao, X.D., Han, X., Chew, J.L., Liu, J., Chiu, K.P., Choo, A., Orlov, Y.L., Sung, W.-K., Shahab, A., Kuznetsov, V.A., Bourque, G., Oh, S., Ruan, Y., Ng, H.-H., Wei, C.-L.
Published 2013

A genome-wide RNAi screen reveals determinants of human embryonic stem cell identity

by Chia, N.-Y., Chan, Y.-S., Feng, B., Lu, X., Orlov, Y.L., Moreau, D., Kumar, P., Yang, L., Jiang, J., Lau, M.-S., Huss, M., Soh, B.-S., Kraus, P., Li, P., Lufkin, T., Lim, B., Clarke, N.D., Bard, F., Ng, H.-H.
Published 2014

Integration of External Signaling Pathways with the Core Transcriptional Network in Embryonic Stem Cells

by Chen, X., Xu, H., Yuan, P., Fang, F., Huss, M., Vega, V.B., Wong, E., Orlov, Y.L., Zhang, W., Jiang, J., Loh, Y.-H., Yeo, H.C., Yeo, Z.X., Narang, V., Govindarajan, K.R., Leong, B., Shahab, A., Ruan, Y., Bourque, G., Sung, W.-K., Clarke, N.D., Wei, C.-L., Ng, H.-H.
Published 2014

Extensive promoter-centered chromatin interactions provide a topological basis for transcription regulation

by Li, G., Ruan, X., Auerbach, R.K., Sandhu, K.S., Zheng, M., Wang, P., Poh, H.M., Goh, Y., Lim, J., Zhang, J., Sim, H.S., Peh, S.Q., Mulawadi, F.H., Ong, C.T., Orlov, Y.L., Hong, S., Zhang, Z., Landt, S., Raha, D., Euskirchen, G., Wei, C.-L., Ge, W., Wang, H., Davis, C., Fisher-Aylor, K.I., Mortazavi, A., Gerstein, M., Gingeras, T., Wold, B., Sun, Y., Fullwood, M.J., Cheung, E., Liu, E., Sung, W.-K., Snyder, M., Ruan, Y.
Published 2013

An oestrogen-receptor-α-bound human chromatin interactome

by Fullwood, M.J., Liu, M.H., Pan, Y.F., Liu, J., Xu, H., Mohamed, Y.B., Orlov, Y.L., Velkov, S., Ho, A., Mei, P.H., Chew, E.G.Y., Huang, P.Y.H., Welboren, W.-J., Han, Y., Ooi, H.S., Ariyaratne, P.N., Vega, V.B., Luo, Y., Tan, P.Y., Choy, P.Y., Wansa, K.D.S.A., Zhao, B., Lim, K.S., Leow, S.C., Yow, J.S., Joseph, R., Li, H., Desai, K.V., Thomsen, J.S., Lee, Y.K., Karuturi, R.K.M., Herve, T., Bourque, G., Stunnenberg, H.G., Ruan, X., Cacheux-Rataboul, V., Sung, W.-K., Liu, E.T., Wei, C.-L., Cheung, E., Ruan, Y.
Published 2014