The pro-regenerative effects of hyperil6 in drug induced liver injury are unexpectedly due to competitive inhibition of il11 signaling

by Dong, Jinrui, Viswanathan, Sivakumar, Adami, Eleonora, Schafer, Sebastian, Kuthubudeen, Fathima F., Widjaja, Anissa A., Cook, Stuart A.
Published 2022

Loss of Yap/taz in cardiac fibroblasts attenuates adverse remodeling and improves cardiac function.

by Mia, Masum M, Cibi, Dasan Mary, Binte Abdul Ghani, Siti Aishah, Singh, Anamika, Tee, Nicole, Sivakumar, Viswanathan, Bogireddi, Hanumakumar, Cook, Stuart A, Mao, Junhao, Singh, Manvendra K
Published 2021

A neutralizing IL-11 antibody reduces vessel hyperplasia in a mouse carotid artery wire injury model

by Schumacher, David, Liehn, Elisa A., Nilcham, Pakhwan, Mayan, David Castano, Rattanasopa, Chutima, Anand, Kaviya, Crespo-Avilan, Gustavo E., Hernandez-Resendiz, Sauri, Singaraja, Roshni R., Cook, Stuart A., Hausenloy, Derek J.
Published 2022

Molecular Dissection of Pro-Fibrotic IL11 Signaling in Cardiac and Pulmonary Fibroblasts

by Widjaja, Anissa A, Viswanathan, Sivakumar, Jinrui, Dong, Singh, Brijesh K, Tan, Jessie, Ting, Joyce Goh Wei, Lamb, David, Shekeran, Shamini G, George, Benjamin L, Schafer, Sebastian, Carling, David, Adami, Eleonora, Cook, Stuart A
Published 2022

Similarities and differences between IL11 and IL11RA1 knockout mice for lung fibro-inflammation, fertility and craniosynostosis

by Ng, Benjamin, Widjaja, Anissa A., Viswanathan, Sivakumar, Dong, Jinrui, Chothani, Sonia P., Lim, Stella, Shekeran, Shamini G., Tan, Jessie, McGregor, Narelle E., Walker, Emma C., Sims, Natalie A., Schafer, Sebastian, Cook, Stuart A.
Published 2022

Feasibility to Perform T-2* Mapping Postcontrast Administration in Reperfused STEMI Patients for the Detection of Intramyocardial Hemorrhage

by Bulluck, Heerajnarain, Chowdhury, Nazia, Lim, Mei Xing, Allen, John C, Bryant, Jennifer A, Chan, Mark Y, Chan, Mervyn HH, Chin, Calvin WL, Ho, Hee Hwa, Lim, Soo T, Tan, Ru-San, Tan, Jack W, Wong, Philip E, Yeo, Khung K, Cook, Stuart A, Hausenloy, Derek J
Published 2021

Targeting endogenous kidney regeneration using anti-IL11 therapy in acute and chronic models of kidney disease

by Widjaja, Anissa A, Viswanathan, Sivakumar, Shekeran, Shamini G, Adami, Eleonora, Lim, Wei-Wen, Chothani, Sonia, Tan, Jessie, Goh, Joyce Wei Ting, Chen, Hui Mei, Lim, Sze Yun, Boustany-Kari, Carine M, Hawkins, Julie, Petretto, Enrico, Huebner, Norbert, Schafer, Sebastian, Coffman, Thomas M, Cook, Stuart A
Published 2023

Hepatocyte-specific IL11 cis-signaling drives lipotoxicity and underlies the transition from NAFLD to NASH

by Dong, Jinrui, Viswanathan, Sivakumar, Adami, Eleonora, Singh, Brijesh K, Chothani, Sonia P, Ng, Benjamin, Lim, Wei Wen, Zhou, Jin, Tripathi, Madhulika, Ko, Nicole SJ, Shekeran, Shamini G, Tan, Jessie, Lim, Sze Yun, Wang, Mao, Lio, Pei Min, Yen, Paul M, Schafer, Sebastian, Cook, Stuart A, Widjaja, Anissa A
Published 2022

Redefining IL11 as a regeneration-limiting hepatotoxin and therapeutic target in acetaminophen-induced liver injury

by Widjaja, Anissa A, Dong, Jinrui, Adami, Eleonora, Viswanathan, Sivakumar, Ng, Benjamin, Pakkiri, Leroy S, Chothani, Sonia P, Singh, Brijesh K, Lim, Wei Wen, Zhou, Jin, Shekeran, Shamini G, Tan, Jessie, Lim, Sze Yun, Goh, Joyce, Wang, Mao, Holgate, Robert, Hearn, Arron, Felkin, Leanne E, Yen, Paul M, Dear, James W, Drum, Chester L, Schafer, Sebastian, Cook, Stuart A
Published 2022

Inhibiting Interleukin 11 Signaling Reduces Hepatocyte Death and Liver Fibrosis, Inflammation, and Steatosis in Mouse Models of Non-Alcoholic Steatohepatitis.

by Widjaja, Anissa A, Singh, Brijesh K, Adami, Eleonora, Viswanathan, Sivakumar, Dong, Jinrui, D'Agostino, Giuseppe A, Ng, Benjamin, Lim, Wei Wen, Tan, Jessie, Paleja, Bhairav S, Tripathi, Madhulika, Lim, Sze Yun, Shekeran, Shamini Guna, Chothani, Sonia P, Rabes, Anne, Sombetzki, Martina, Bruinstroop, Eveline, Min, Lio Pei, Sinha, Rohit A, Albani, Salvatore, Yen, Paul M, Schafer, Sebastian, Cook, Stuart A
Published 2019

Systematic large-scale assessment of the genetic architecture of left ventricular noncompaction reveals diverse etiologies

by Mazzarotto, Francesco, Hawley, Megan H., Beltrami, Matteo, Beekman, Leander, De Marvao, Antonio, Mcgurk, Kathryn A., Statton, Ben, Boschi, Beatrice, Girolami, Francesca, Roberts, Angharad M., Lodder, Elisabeth M., Allouba, Mona, Romeih, Soha, Aguib, Yasmine, Baksi, A. John, Pantazis, Antonis, Prasad, Sanjay K., Cerbai, Elisabetta, Yacoub, Magdi H., O’Regan, D.P., Cook, Stuart A., Ware, James S., Funke, Birgit, Olivotto, Iacopo, Bezzina, Connie R., Barton, Paul J. R., Walsh, Roddy
Published 2022

Disease-specific variant pathogenicity prediction significantly improves variant interpretation in inherited cardiac conditions

by Zhang, Xiaolei, Walsh, Roddy, Whiffin, Nicola, Buchan, Rachel, Midwinter, William, Wilk, Alicja, Govind, Risha, Li, Nicholas, Ahmad, Mian, Mazzarotto, Francesco, Roberts, Angharad, Theotokis, Pantazis I., Mazaika, Erica, Allouba, Mona, de Marvao, Antonio, Pua, Chee Jian, Day, Sharlene M., Ashley, Euan, Colan, Steven D., Michels, Michelle, Pereira, Alexandre C., Jacoby, Daniel, Ho, Carolyn Y., Olivotto, Iacopo, Gunnarsson, Gunnar T., Jefferies, John L., Semsarian, Chris, Ingles, Jodie, O’Regan, D.P., Aguib, Yasmine, Yacoub, Magdi H., Cook, Stuart A., Barton, Paul J. R., Bottolo, Leonardo, Ware, James S.
Published 2022

Genetic Studies of Hypertrophic Cardiomyopathy in Singaporeans Identify Variants in TNNI3 and TNNT2 That Are Common in Chinese Patients

by Pua, Chee Jian, Tham, Nevin, Chin, Calvin WL, Walsh, Roddy, Khor, Chiea Chuen, Toepfer, Christopher N, Repetti, Giuliana G, Garfinkel, Amanda C, Ewoldt, Jourdan F, Cloonan, Paige, Chen, Christopher S, Lim, Shi Qi, Cai, Jiashen, Loo, Li Yang, Kong, Siew Ching, Chiang, Charleston WK, Whiffin, Nicola, de Marvao, Antonio, Lio, Pei Min, Hii, An An, Yang, Cheng Xi, Le, Thu Thao, Bylstra, Yasmin, Lim, Weng Khong, Teo, Jing Xian, Padilha, Kallyandra, Silva, Gabriela V, Pan, Bangfen, Govind, Risha, Buchan, Rachel J, Barton, Paul JR, Tan, Patrick, Foo, Roger, Yip, James WL, Wong, Raymond CC, Chan, Wan Xian, Pereira, Alexandre C, Tang, Hak Chiaw, Jamuar, Saumya Shekhar, Ware, James S, Seidman, Jonathan G, Seidman, Christine E, Cook, Stuart A
Published 2021

Author Correction: Characterising the loss-of-function impact of 5’ untranslated region variants in 15,708 individuals (Nature Communications, (2020), 11, 1, (2523), 10.1038/s41467...

by Whiffin, Nicola, Karczewski, Konrad J., Zhang, Xiaolei, Chothani, Sonia, Smith, Miriam J., Evans, D. Gareth, Roberts, Angharad M., Quaife, Nicholas M., Schafer, Sebastian, Rackham, Owen, Alföldi, J., O’Donnell-Luria, A.H., Francioli, Laurent C., Armean, Irina M., Banks, E., Bergelson, L., Cibulskis, K., Collins, R.L., Connolly, K.M., Covarrubias, M., Cummings, B., Daly, M.J., Donnelly, S., Farjoun, Y., Ferriera, S., Gabriel, S., Gauthier, L.D., Gentry, J., Gupta, N., Jeandet, T., Kaplan, D., Laricchia, K.M., Llanwarne, C., Minikel, E.V., Munshi, R., Neale, B.M., Novod, S., Petrillo, N., Poterba, T., Roazen, D., Ruano-Rubio, V., Saltzman, A., Samocha, K.E., Schleicher, M., Seed, C., Solomonson, M., Soto, J., Tiao, G., Tibbetts, K., Tolonen, C., Vittal, C., Wade, G., Wang, A., Wang, Q., Watts, N.A., Weisburd, B., Aguilar Salinas, Carlos A., Ahmad, T., Albert, C.M., Ardissino, D., Atzmon, G., Barnard, J., Beaugerie, L., Benjamin, E.J., Boehnke, M., Bonnycastle, L.L., Bottinger, E.P., Bowden, D.W., Bown, M.J., Chambers, J.C., Chan, J.C., Chasman, D., Cho, J., Chung, M.K., Cohen, B., Correa, A., Dabelea, D., Daly, M.J., Darbar, D., Duggirala, R., Dupuis, J., Ellinor, P.T., Elosua, R., Erdmann, J., Esko, T., Färkkilä, M., Florez, J., Programs in Metabolism and Medical and Population Genetics, Broad Institute., Department of Medicine, Harvard Medical School, Boston, MA 02115, United States., Franke, A., Getz, G., Glaser, B., Glatt, S.J., Goldstein, D., Gonzalez, C., Groop, L., Haiman, C., Hanis, C., Harms, M., Hiltunen, M., Holi, M.M., Hultman, C.M., Kallela, M., Kaprio, J., Kathiresan, S., Kim, B.-J., Kim, Y.J., Kirov, G., Kooner, J., Koskinen, S., Krumholz, H.M., Kugathasan, S., Kwak, S.H., Laakso, M., Lehtimäki, T., Loos, R.J.F., Lubitz, S.A., Ma, R.C.W., Marrugat, J., Mattila, K.M., McCarroll, S., McCarthy, M.I., McGovern, D., McPherson, R., Meigs, J.B., Melander, O., Metspalu, A., Neale, B.M., Nilsson, P.M., O’Donovan, M.C., Ongur, D., Orozco, L., Owen, M.J., Palmer, C.N.A., Palotie, A., Park, K.S., Pato, C., Pulver, A.E., Rahman, N., Remes, A.M., Rioux, J.D., Ripatti, S., Roden, D.M., Saleheen, D., Salomaa, V., Samani, N.J., Scharf, J., Schunkert, H., Shoemaker, M.B., Sklar, P., Soininen, H., Sokol, H., Spector, T., Sullivan, P.F., Suvisaari, J., Tai, E. Shyong, Teo, Yik Ying, Tiinamaija, T., Tsuang, M., Turner, D., Tusie-Luna, T., Vartiainen, E., Watkins, H., Weersma, R.K., Wessman, M., Wilson, J.G., Xavier, R.J., Vawter, M.P., Cook, Stuart A., Barton, Paul J. R., MacArthur, Daniel G., Ware, James S.
Published 2022

Publisher Correction: LifeTime and improving European healthcare through cell-based interceptive medicine (Nature, (2020), 587, 7834, (377-386), 10.1038/s41586-020-2715-9)

by Rajewsky, Nikolaus, Almouzni, Genevieve, Gorski, Stanislaw A., Aerts, Stein, Amit, Ido, Bertero, Michela G., Bock, Christoph, Bredenoord, Annelien L., Cavalli, Giacomo, Chiocca, Susanna, Clevers, Hans, De Strooper, Bart, Eggert, Angelika, Ellenberg, Jan, Fernández, X.M., Figlerowicz, Marek, Gasser, Susan M., Hubner, Norbert, Kjems, Jorgen, Knoblich, Jurgen A., Krabbe, Grietje, Lichter, Peter, Linnarsson, Sten, Marine, Jean-Christophe, Marioni, John C., Marti-Renom, Marc A., Netea, Mihai G., Nickel, Dorthe, Nollmann, Marcelo, Novak, Halina R., Parkinson, Helen, Piccolo, Stefano, Pinheiro, Ines, Pombo, Ana, Popp, Christian, Reik, Wolf, Roman-Roman, Sergio, Rosenstiel, Philip, Schultze, Joachim L., Stegle, Oliver, Tanay, Amos, Testa, Giuseppe, Thanos, Dimitris, Theis, Fabian J., Torres-Padilla, Maria-Elena, Valencia, Alfonso, Vallot, Celine, Van Oudenaarden, Alexander, Vidal, Marie, Voet, Thierry, Alberi, L., Alexander, S., Alexandrov, T., Arenas, E., Bagni, C., Balderas, R., Bandelli, A., Becher, B., Becker, M., Beerenwinkel, N., Benkirane, M., Beyer, M., Bickmore, W.A., Biessen, E.E.A.L., Blomberg, N., Blumcke, I., Bodenmiller, B., Borroni, B., Boumpas, D.T., Bourgeron, T., Bowers, S., Braeken, D., Brooksbank, C., Brose, N., Bruining, H., Bury, J., Caporale, N., Cattoretti, G., Chabane, N., Chneiweiss, H., Cook, Stuart A., Curatolo, P., de Jonge, M.I., Deplancke, B., de Witte, P., Dimmeler, S., Draganski, B., Drews, A., Dumbrava, C., Engelhardt, S., Gasser, T., Giamarellos-Bourboulis, E.J., Graff, C., Grün, D., Gut, I.G., Hansson, O., Henshall, D.C., Herland, A., Heutink, P., Heymans, S.R.B., Heyn, H., Huch, M., Huitinga, I., Jackowiak, P., Jongsma, K.R., Journot, L., Junker, J.P., Katz, S., Kehren, J., Kempa, S., Kirchhof, P., Klein, C., Koralewska, N., Korbel, J.O., Kühnemund, M., Lamond, A.I., Lauwers, E., Le Ber, I., Leinonen, V., López-Tobón, A., Lundberg, E., Lunkes, A., Maatz, H., Mann, M., Marelli, L., Matser, V., Matthews, P.M., Mechta-Grigoriou, F., Menon, R., Nielsen, A.F., Pagani, M., Pasterkamp, R.J., Pitkänen, A., Popescu, V., Pottier, C., Puisieux, A., Rademakers, R., Reiling, D., Reiner, O., Remondini, D., Ritchie, C., Rohrer, J.D., Saliba, A.-E., Sanchez-Valle, R., Santosuosso, A., Sauter, A., Scheltema, R.A., Scheltens, P., Schiller, H.B., Schneider, A., Seibler, P., Sheehan-Rooney, K., Shields, D.J., Sleegers, K., Smit, A.B., Smith, K.G.C., Smolders, I., Synofzik, M., Tam, W.L., Teichmann, S.A., Thom, M., Turco, M.Y., van Beusekom, H.M.M., Vandenberghe, R., Van den Hoecke, S., van de Poel, I., van der Ven, A., van der Zee, J., van Lunzen, J., van Minnebruggen, G., Van Oudenaarden, Alexander, Van Paesschen, W., van Swieten, J.C., van Vught, R., Verhage, M., Verstreken, P., Villa, C.E., Vogel, J., von Kalle, C., Walter, J., Weckhuysen, S., Weichert, W., Wood, L., Ziegler, A.-G., Zipp, F., LifeTime Community Working Groups.
Published 2022